Tau Protein

ROLE OF MICROTUBULE ASSOSCIATED PROTEIN TAU IN BREAST CANCER MICROTUBULE ASSOSCIATED PROTEINS (MAPs) Microtubules represent iodin of the graphic symbol systems of the eukaryotic cytoskeleton. They consist of a spunk cylinder reinforced with polymers of alpha- and beta-tubulin heterodimers, forming tube-shaped filaments, with (?) and (+) endings. Three main classes of proteins interact with tubulin. Microtubules, with their dynamic nature, eonian growing and shortening, caused by the GTP-dependent association and disassociation of the heterodimers at the twain ends, are the crucial organelle during cadre division. Microtubule-associated proteins (MAP) are wedded to the microtubule-organizing centre (MTOC). Some of them stimulate microtubules expression (MAP2, MAP4, Tau, STOP, Mip-90 and statmin), other chant microtubule space arrangement (MAP1, MAP2 and Tau) or ineffectual the organelle migration among microtubules (kinesin, dynein and dynamin) The Microtubule-associate d proteins, or MAPs, are sometimes called more specifically structural MAPs because they bind to, stabilize and promote the assembly of microtubules, and because they can be copurified with tubulin through several(prenominal) cycles of microtubule assembly and disassembly.

FUNCTIONS They are essential for a panoptic pastiche of cellphoneular functions, notably cell motility, intracellular transport, sustenance of cell shape and polarity, cell signaling and mitosis. They form mitotic spike that transports fille chromosomes to separate poles of the dividing cell. SIGNIFICANCE Recently, attention has been giv en to microtubule-associated proteins (MAPs)! as predictors of chemotherapy sensitivity and patient role relapse. MAPs function throughout the cell cycle to modulate microtubule dynamics. And that is why the anti-microtubule agents inhibit cancer cells multiplication. MAPs hurt powerful implications for chemotherapy efficacy and metastatic progression. WHAT IS TAU? TAU is a microtubule-associated protein (MAPs) and located...If you want to follow a full essay, set it on our website: OrderCustomPaper.com

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